The Noodist boys are back for another episode of Noodles at Never Again. In this episode, Ben announces some major life news, Michael announces some major life news, and Noah announces some major dishwasher news.
Games this week: “What’s the deal with?: JAMA edition”
WTDW JAMA:
Smell – Swedish study with >2,500 participants >72yo, smell lemon to garlic to coffee, groups with more incorrect answers (anosmic), nearly 70% increased relative risk of all cause mortality than the normosmic group. Likely frailty, safety Sense of Smell Is a Marker for Mortality Risk, With Dementia and Frailty as Key Mediators | Olfaction and Taste | JAMA | JAMA Network
The Ukraine – Dr. Rudenko treating something called obstructive HCM (shoutout to Gizzy) and has been doing surgery to treat it since 2016. He stayed at the Amosov Institute – Kyiv in spite of being awoken by bombs and he has performed 380 out of 868 septal myectomy operations during conditions of war. Emergency generators, no loss of ventilators Surgical Treatment of Hypertrophic Cardiomyopathy in Ukraine During War | Humanities | JAMA Cardiology | JAMA Network
Metformin – Many have heard of this medication; belongs to the class of antihyperglycemics (oral biguanide), meaning lowers sugars often in the context of pre DM or DM, PCOS. Obesity related osteoarthritis occurs in 365M ppl worldwide, excess weight bearing on jts, impaired metabolism leading to inflammation. RCT of 107 ppl. At 6 months, pain difference was stat sig P=.01. ADRs → diarrhea, adb discomfort https://jamanetwork.com/journals/jama/fullarticle/2833338?guestaccesskey=b11d22bd-e66a-4484-9bc4-3519bfff5acc&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf&utm_term=042425&utm_adv=
Greenhouse Gas Emissions – Metered dose inhalers in 2022 output estimated 1.15M metric tons CO2 -> equiv to annual electricity of 300,000 homes. Dry powder and soft mist inhalers have no propellants and estimated 1kg CO2 emissions per inhaler whereas metered is 48.1kg CO2. They pontificated on the cost and availability of these alternatives and raising awareness. https://jamanetwork.com/journals/jama/fullarticle/2833427
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